Harnessing the Electrophilicity of Keteniminium Ions: A Simple and Straightforward Entry to Tetrahydropyridines and Piperidines from Ynamides
نویسندگان
چکیده
An efficient, modular and straightforward entry to tetrahydropyridines and piperidines is reported. This reaction is based on a formal intramolecular hydroalkylation of readily available, properly substituted ynamides which, upon simple activation under acidic conditions, generate highly reactive activated keteniminium ions whose reactivity can be finely controlled to induce a remarkably efficient [1,5]-hydride shift from unactivated C-H bonds and trigger a cationic cyclization which is complete within minutes.
منابع مشابه
Investigation of relationship with electron configuration of chemical hardness, absolute electronegativity and electrophilicity
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